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Mixing different drugs can be very dangerous and should be avoided unless allowed or directed by a doctor. I do not know about hydrocodone-homatropine and NyQuil, but mixing drugs can quite frequently amplify the effects of both. The side effects of mixing drugs are frequently unknown - part of the reason why it is dangerous to do so.

Four things could happen:

1) The two drugs do not interact, or interact linearly and simply add on top of each other. This is the best case.

2) The two drugs have opposite effects - reducing the effectiveness of some effects, potentially making you think it is OK to take more (even though the toxicity of the drugs remain). This is what happened with caffeinated Alcoholic Beverages: the caffeine acted as a stimulant, counteracting the depressive effects of alcohol, making people think that they less drunk than they really were. Because of this, people drinking these caffeinated alcoholic beverages were more likely to drink fatal amounts, and were just as impaired as if they had drunk the same amount of an uncaffeinated alcoholic beverage.

3) The two drugs react without other and create new and unexpected side effects, which either drug will not produce on its own.

4) The two drugs amplify each other, making them FAR more potent than they should be. This is actually very common with alcohol, which is why drugs almost always have warnings not to take with alcohol.

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Q: What are the side effects of mixing hydrocodone-homatropine syrup with NyQuil?
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