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From http://www.spectrumpharm.com/sumatriptan.html on 3July2008: On October 2004, we filed with the FDA an abbreviated new drug application (ANDA) with a paragraph IV certification, for sumatriptan succinate injection 6mg/0.5mL, seeking approval to engage in the commercial manufacture, sale, and use of the sumatriptan succinate injection product in the United States. Sumatriptan succinate is marketed by GlaxoSmithKline under the brand name Imitrex®. On February 18, 2005, GlaxoSmithKline filed a lawsuit against Spectrum Pharmaceuticals in the United States District Court in the District of Delaware, alleging infringement of the Imitrex® patent. In November 2006, Spectrum and GSK reached an agreement to settle the patent litigation relating to sumatriptan injection. The terms of the confidential agreement provide that Spectrum may exclusively distribute authorized generic versions of certain sumatriptan injection products in the United States with an expected launch during GSK's sumatriptan pediatric exclusivity period which begins on August 6, 2008, but with the launch occurring not later than November 6, 2008. Spectrum will launch sumatriptan injection through its partner for the sale and distribution of the drug, Par Pharmaceutical Companies, Inc.
Sumatriptan has been tested on animals.
what is ammonium succinate? An amino acid
Malonate is a competitive inhibitor of succinate dehydrogenase, the enzyme responsible for converting succinate to fumarate in the citric acid cycle. Malonate resembles succinate and competes for the active site of succinate dehydrogenase. As a result, malonate binds to the enzyme and prevents succinate from binding, inhibiting the conversion of succinate to fumarate.
Yes. I've taken Sumatriptan for migraines for almost 2 years now. Frequent urination after taking it is listed as a common side effect. It subsides within a few hours.
There are no known drug interactions between sumatriptan and depo provera
Malonate is a competitive inhibitor preventing the substrate succinate from binding to the enzyme. The structure of succinate is comparable to that of malonate but for the ability for malonate to bind to an enzyme but then cannot further act on it creating a nonproductive complex.
light blue oval shaped pill scored on one side and "44386" imprinted on the other side.
Yes. Since late 2008. See http://nervous-system.emedtv.com/sumatriptan/generic-sumatriptan.html
Metoprolol tartrate and succinate are used for the same purpose, the tartrate being a generic version of Lopressor and succinate being a generic version of Toprol XL.The active chemical is different, however, so it effects may be somewhat different.According to wikipedia.org, "the active substance metoprolol is employed either as metoprolol succinate or metoprolol tartrate (whereas 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate), respectively as prolonged-release or conventional-release formulation."I tried both tartrate and succinate, and found a difference in my body reaction. The Tartrate gave me a dry mouth upon awakening in the morning and made my tongue feel a slight tingle. Because I had to take it twice a day, I occasionally forgot to take the second pill. I prefer the Metoprolol Succinate ER. No side effects and conveniently taken once a day. I did experience a difference.
Malonic acid is a competitive inhibitor of succinate dehydrogenase.