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1. Lack of gravity - no gravity caused bone loss and other changes in the human body.

2. Radiation - deadly radiation from the sun and cosmic rays can damage human tissue or even kill astronauts if they get overexposure to radiation for which there is little or no protection in outer space.

3. Isolation - no one has been that far from Earth before and little is known about the long term effects of being cut off from Earth and other humans.

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