Interstate 70 and 25.
highways and interstates
2,3,9,6,10,5
Interstates 25, 70, and 76.US Highways 50, 287, 40, 6, 83, 84, 85, 24, and 285.
Interstates 40, 44 and 35
poo
The highest speed limit on the Interstates is 75 MPH.
u.s. and state routes and interstates
95, 64, 81, and 85 all cross major rivers.
The Colorado, and Green River!
Colorado and/or Rio Grande
A good site for finding a map of West Virginia's major roads and cities would be geology.com. It shows all of West Virginia's major interstates and cities, and has different types of map, depending on what you are looking for.
AIMCO, Johns Manville Corporation and MapQuest.