It depends what you imagine "Shakespeare's interest" to be. There is no external evidence that he had any interests of any kind apart from making money and social climbing. So, maybe Timon of Athens (which is about losing money, not making it) and Richard III (who is sort of a social climber).
Depending on the cuts, Shakespearean plays run two to three hours.
This is a matter of opinion, but Hamlet and King Lear are usually the plays mentioned as Shakespeare's best.
King John, Henry VIII, The Two Gentlemen of Verona, Timon of Athens and Cymbeline.
There are no specific records of which were the first two plays Shakespeare had performed. There is a great deal of speculation. There are records of the first publications, but that is not the same thing.
The most famous role for an animal is the dog Crab in The Two Gentlemen of Verona. It is also possible that there was a real bear in The Winter's Tale.
Two tragedies: Timon of Athens and Titus Andronicus Two histories: King John and Henry VI Part 1 Two comedies: Pericles and Love's Labour's Lost
"Best" is of course a subjective thing, but the most popular are Richard II, the two parts of Henry IV, Henry V and Richard III.
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Assuming you meant professions, Shakespeare was an actor, a poet and a playwright. He also owned shares in the acting company in which he performed and which put on his plays, and in the two theaters in which the company performed.
He had two: one born in 1583 and another in 1585.
Titus Andronicus, Henry VI Part II, Henry VI Part III, Love's Labour's Lost, The Two Gentlemen of Verona, The Comedy of Errors. Take your pick.
A typical performance might run two-and-a-half hours.