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A nuclear reactor is usually fueled with Uranium oxide, normally known as yellowcake because it is yellow. Some reactors are fueled with MOX, Mixed OXide fuel containing both Uranium and Plutonium oxides. After a reactor has run a few months it has breed several transuranics including Plutonium, Americium, and Curium (yes, all reactors breed transuranics, many of which are usable fuels, not just breeder reactors) which it begins to burn too.

So I have no idea what you mean by "two substances", all reactors within a few months of startup are burning almost every element from Uranium through the highest transuranic element they can breed (which depends on neutron flux and energy spectrum) regardless of what they were fueled with originally.

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