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Cobalt-60 is used in many common industrial applications, such as in leveling devices and thickness gauges, and in radiotherapy in hospitals. Large sources of cobalt-60 are increasingly used for sterilization of spices and certain foods.

The powerful gamma rays kill bacteria and other pathogens, without damaging the product. After the radiation ceases, the product is not left radioactive. This process is sometimes called "cold pasteurization."

Cobalt-60 is also used for industrial radiography, a process similar to an x-ray, to detect structural flaws in metal parts. One of its uses is in a medical device for the precise treatment of otherwise inoperable deformities of blood vessels and brain tumors. Radionuclides, such as cobalt-60, that are used in industry or medical treatment are encased in shielded metal containers or housings, and are referred to as radiation 'sources.' The shielding keeps operators from being exposed to the strong radiation.

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