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Down syndrome is the most common genetic cause of ID (intellectual disability). Down syndrome is caused by trisomy for chromosome specifically, duplication of 21q22.

  • 95% of cases result from nondisjunction and resultant standard trisomy 21.
  • The remaining 5% are relatively evenly split between robertsonian translocation, of which 14;21 translocation is most common and about half are familial.

note :

robertsonian translocation is a common form of chromosomal rearrangement that in humans occurs in the five acrocentric chromosome pairs, namely 13, 14, 15, 21, and 22.

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Lulu Pfannerstill

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12y ago

down syndrome is the most common genetic cause of ID (intellectual disability). Down syndrome is caused by trisomy for chromosome specifically, duplication of 21q22.

  • 95% of cases result from nondisjunction and resultant standard trisomy 21.
  • The remaining 5% are relatively evenly split between robertsonian translocation, of which 14;21 translocation is most common and about half are familial.

note :

robertsonian translocation is a common form of chromosomal rearrangement that in humans occurs in the five acrocentric chromosome pairs, namely 13, 14, 15, 21, and 22.

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8y ago

There is only one and that is an extra chromosome.

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Q: What are two major causes responsible for Down syndrome?
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Related questions

Are women responsible for the Down syndrome disease?

No


Is it true to state that female only are responsible for down syndrome?

no and waverer some kids have down syndrome


What trisomy causes Down syndrome?

Down syndrome is caused by the presence of a third chromosome 21


What pathogen causes Down syndrome?

bacteria


Does Down Syndrome causes childlike behavior?

yes it causes childlike symptoms


What are some common causes of retardation?

There are many causes of retardation. These includes Down syndrome, velocariofacial syndrome, fetal alcohol syndrome, problems during pregnancy and other genetic disorders.


Causes Down Syndrome?

Having an extra copy of chromosome 21. You are supposed to have 2; when you have 3 (trisomy 21), Down's Syndrome is the result.


Can medication for gallstones during pregnancy cause Down syndrome?

See the Related Link to a very good FAQ on the causes of Down syndrome.


Why do people get down syndrome is it purely genetic?

Down syndrome is purely genetic. There are no known environmental causes of the disorder. It is not a disease that is passed from parent to child. It is simply an disorder when the chromosomes split during cell division during development. The mayoclinic describes the causes: http://www.mayoclinic.com/health/down-syndrome/DS00182/DSECTION=causes


Why did evolution not occur in down syndrome?

Down Syndrome is a the addition of an extra chromosome and not really related to evolution. It is more of a genetic mutation that causes this event to occur.


What causes Irukandji Syndrome?

Quote from Wikipedia: "Irukandji syndrome is a condition induced by envenomization through the sting of Carukia barnesi, the Irukandji jellyfish, and other cubozoans.[1]"Note: Irukandji Syndrome has nothing to do with Down Syndrome and this question should NOT be placed in the Down Syndrome category!


What is the name of the genetic makeup that causes Down syndrome?

dana hills high school