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Prevention of bovine spongiform encephalopathy (BSE) is mainly through a rendering and feed ban. Prior to the early 1990s, it was common for dead cattle to be rendered (cooked at high temperatures to separate the fat from the protein of the carcass) and for the protein from this process to be fed back to cattle as a protein supplement. However, it was discovered that the BSE prion is not broken down during rendering (as had been previously assumed) and that this was how the prion was being transmitted through the herd.

After vCJD was identified and linked to BSE in cattle, this practice has been banned around the world and infectious BSE cases have dropped to almost zero since then.

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