the world was being re-shaped, the Jews did not figure into the Nazi vision of an ideal society, the persecution was their way of realizing their vision
that it was nonsense.
By the issue that it was an action of Nazis against Jews.
The rapid radicalization of Nazi antisemitism.
Kristallnacht or the Night of Broken Glass in November 1938 changed the tone of Jewish persecution in Nazi Germany from only a legal segregation between Germans and Jews to actual violent persecution, theft, and murder of Jews.
I don't think the Nazi persecution of the Jews had any bearing on the '''outcome''' of World War 2. The war (unlike the Holocaust) was not about the Jews.
By the issue that it was an action of Nazis against Jews.
Kristallnacht
cock
There was no single year. The Nazi persecution of the Jews led to increased immigration to the then Mandate of Palestine from 1933 onwards.
The persecution (systematic harassment by the government) of the Jews in Nazi Germany very soon after the Nazis came to power in 1933. Please see the related question for details. Moreover, if Jews were beaten up by Nazi stormtroopers the police did nothing to protect them.
There were many groups targeted for persecution by the Nazis. But the group that was hardest targeted and suffered a greater proportion of deaths than even the Jews were the Gypsies.