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What causes high protime levels when you are on coumadin?
Darlamaej
Your "ProTime" is actually the prothombinase time, or time to coagulation. Coagulation cascade is a complex interaction of chemicals but to put it shortly prothombinase is the first step in forming a clot. Coumadin (warafin) has the effect of preventing prothombin formation (once again this is simplified but meant to be easily understood) prothombin forms thrombin whick allows clotting. Without prothombin there is no/less clotting. The reason your PTT (prothombin time) is monitored is to keep it in a narrow theraputic range not too fast not too slow. Elevated PTT is good, too high and hemmorhage is a risk. Your dietary consumption of Vit K will counteract warafin's effectivness, so changes in diet can throw off your PTT. Maintaining the same Vit K intake will help clinicians keep you warafin dose in the theraputic range.
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