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The cells primarily responsible for the breakdown of bone are?
Osteoclasts are the cells primarily responsible for the breakdown of bone. They are derived from monocytes and become multinucleated cells that secrete acids and enzymes to dissolve the mineralized matrix of bone.
The factor that determine where bone matrix is to be remodeled is?
The factors that determine where bone matrix is to be remodeled include mechanical stress on the bone, hormonal factors, and local growth factors. Osteocytes sense these factors and signal bone remodeling to maintain bone strength and integrity.
Which of the following characteristics applies to the cells known as osteoclasts?
Osteoclasts are large, multinucleated cells found in bone tissue. They are responsible for the breakdown and resorption of bone by secreting enzymes and acids that dissolve the mineralized matrix of bone. Osteoclasts are derived from the fusion of monocytes/macrophages and are involved in bone remodeling and repair.
What drugs inhibit the breakdown of bone?
Bisphosphonates are the primary class of drugs that inhibit the breakdown of bone. They work by binding to the bone mineral matrix and preventing osteoclasts from breaking down bone tissue. Other medications, such as denosumab (a monoclonal antibody) and selective estrogen receptor modulators (SERMs) like raloxifene, also have similar effects on bone breakdown. These drugs are commonly used in the treatment of osteoporosis and other bone-related conditions.
What are the cells that produce organic matrix in bone?
The cells that produce the collagen and inorganic salts of bone matrix are osteocytes. Osteocytes maintain the protein and mineral content of the bone matrix. Osteogenesis is the production of new bone matrix.
Which bone cell destroys and recycles bones?
Osteoclasts are the cells that breakdown bones by releasing enzymes and resorbing the bones. This sounds negative but it's actually very important for bone health because it allows your bones to be remodeled. About 10% of adult bones are remodeled in a year; in the first year of life, almost 100% of the skeleton is remodeled and replaced.
What are immature or matrix-depositing bone cells?
Immature or matrix-depositing bone cells are osteoblasts. These cells are responsible for bone formation by secreting collagen and other proteins that make up the bone matrix. Osteoblasts play a crucial role in bone growth and remodeling.
What is the organic component of the matrix in developing or repairing bone?
The organic component of the bone matrix is primarily made up of collagen fibers, which provide flexibility and strength to the bone. Collagen is produced by bone cells called osteoblasts and helps in bone formation and repair processes.
Bone matrix is produced by?
osteoblasts
What are bones cells that liquefy bone matrix and release calcium to the blood called?
Bone cells that liquefy the bone matrix and release calcium into the blood are called Osteoclasts. Immature or matrix depositing bone cells are called osteoblasts.
What happens through the action of osteoclasts?
Osteoclasts are responsible for bone resorption or the breakdown of bone tissue. They secrete enzymes and acids that dissolve the mineral component of bone, allowing the release of stored calcium and other minerals into the bloodstream. This process helps maintain calcium homeostasis, remodel damaged bone, and play a role in bone growth and repair.
What is the breakdown of bone matrix?
The matrix of the bone is portion of specialized connective tissue composed of intercellular, is contain an organic and inorganic materials 1- The organic material: collagen ( type I) 2- The inorganic material: calcium phosphate
