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Dear Reader; After that long you may experience as much of a change as when you started or no change. Getting weight off could be difficult. Depo can linger any where from a month to over a year. Your health care provider might be able to make a prediction for you. Remember I said might. Dwight

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Q: What changes can you expect after being on Depo Shot for 20 years with no periods at all. I have gained 20 pounds in the last 6 mnths and am now no longer on depo. When will my period return?
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