It depends on your method of travel
79 miles
No, you would get onto I75 a little north of Gainesville. Take I75 SB to either I4 West or I275 South, depending on where in Tampa you are heading.
401 south to Windsor I75 South to Florida 2,152 km - about 20 hours 42 mins
I75 would take you way out of your way. You would get their much quicker by taking I4.
Interstate 75 (I-75) begins in the city of Miami, Florida, and extends northward to its northern terminus in Sault Ste. Marie, Michigan, near the Canadian border. It spans approximately 1,786 miles, making it one of the longest north-south highways in the United States.
Its about 15-16 hours, taking I75 south to I40 east. Its located in the Smoky Mountains of Tennessee.
250
75
Cincinnati Northern Kentucky International Airport ( I75 and I275 junction )is within a mile of half way According to our friends at Google Maps
If you drove 5 hours south on I-75 from Monroe, MI, you would likely end up near the area of Toledo, Ohio, or slightly further, depending on traffic and driving speed. This route typically covers around 300-350 miles, putting you in a region close to the northern border of Kentucky. You would be traveling through a mix of urban and rural areas along the way.
184 miles
Exit 384 is one of them. I think that is Archer.