The Aztecs controlled central Mexico in the beginning of the sixteenth century.
Spain.
The Spanish started colonies in the Caribbean, Mexico and Central/South America in the early sixteenth century.
from the Spanish conquistadors who over-ran Mexico and Peru in the sixteenth century. In the flowers of the vine, they saw various symbols of the Passion of Christ
Conquistadors
Conquistadors conquered Mexico, Peru, Panama, and virtually all of what is now Latin America.
Mexico
Smallpox qualifies as such. It killed off more than 25-50 million people, leaving Mexico with only 1-2 million by 1550.
Panfilo de Narvaez represented Spain during the Age of Exploration, particularly in the early 16th century. He led an expedition to conquer and explore new territories in the Americas, including what is now Florida and parts of Mexico.
Spain is in Europe, Mexico is in North America.
The Aztec civilization lived in Mesoamerica, specifically in the Central Valley of Mexico. They founded their capital city, Tenochtitlan, on an island in Lake Texcoco, which is present-day Mexico City.
Mexico.