No volcano has ever destroyed Vatican City.
Most of it was destroyed by Emperor Aurelian when he reconquered the city. But a lot of it is underwater.
The city of Darwin was almost decimated by Cyclone Tracy in December 1974. There is no city that was virtually destroyed in 1973.
Pompeii, Herculaneum and Stabiae were the cities that were mainly affected. The most famous city would be Pompeii.
Tokyo, Japan
London
A catastrophic fire destroyed a large area of London in 1666.
London
London is the answer for the question. <($_$)>
Fire
It was destroyed in 1666
The great fire of London.
The Great Fire of London started on September 2, 1666. it continued to sweep through the city until September 5, 1666. 87 churches and 13,200 houses were destroyed in the blaze.
The Great Fire of London.
England and the Netherlands went to war. A large portion of the City of London was destroyed by a fire, including St. Paul's Cathedral.
Old St. Paul's .
In September of 1666, fire broke out in a London bakery. The resulting blaze threatened to destroy the city. It destroyed many buildings but loss of life was limited to as few as five people.