At first they did not know how to farm and hunt, and many of them were too busy looking for gold to be bothered with such things. Thus they faced hunger, even starvation. Relations with the Powhatan Indians were rocky. Although the Indians sometimes provided food, they also sometimes kept Jamestown virtually under siege. When no gold was found the colonists had no product with which to trade with England for basic necessities they could not produce themselves, things like farm implements, tools, clothes and firearms. That made it very difficult for them to obtain these necessary things until they learned how to grow tobacco, which was valuable and could be traded for things. They suffered from diseases from mosquitoes, no knowledge of growing crops, no fresh water, no knowledge of raising livestock.
There is a link below that goes even more in detail and has more problems that colonists faced at Jamestown.
many jamestown colonists became sick from malaria and from the drinking water
How did Jamestown colonists adapt to their environment?
the colonists came from England
they walked. or paddled canoes
About 104 colonists
Beginning in 1607.
weapons
It Was the Powhatan
When colonists started growing tobacco
John Smith was the leader of the Jamestown settlers
no way Jose, the Jamestown settlers had to get help from the powhattans because the colonists were invading their lands
Jamestown