I'm not really sure exactly what you mean, but Daniel Boone's Wilderness Trail was utilized by him and his followers to cross through the Appalachian Mt Range. You can find more information on it here: http://www.danielboonetrail.com/
settlers Wanted cross the Appalachians because
It was hard to cross the Appalachians and it made travel difficult and dangerous
During the Civil War the soldiers of both sides had sometimes to cross the Appalachians.
The Proclamation of 1763 established a Proclamation Line along the Appalachians, which the colonists were not allowed to cross.
Appalachians
There are thousands of towns west of the Appalachians.
Daniel Boonie ............ meco
The Alleghenies comprise the rugged western-central portion of the Appalachians.
What the hell else would they be? Downward mountains? Use ya noggin'
A very old range of mountains in the eastern US are called the Appalachians.
American Indians controlled the land west of the Appalachians.
The Appalachians have been worn down by millions of years of weathering and erosion.