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They are many:

  • Ethical problems: for example, if you strongly suspect that a pharmaceutical is valuable then you should not withhold it from patients; however, without withholding it from some patients there is no way of making a comparison to learn what its benefits might be.
  • Effects of concomitant medications: It's almost inevitable that patients will use other medications besides the one of interest. How can we be sure that any benefits, or harm, resulted from the medication being studied?
  • Patients cannot be forced to continue to participate: If a patient drops out of a trial is it because she was cured? Or because she was too sick to continue?
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12y ago

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