From where?
Florence is north of Rome.
Constantinople was approximately 800 miles east from Rome.
You would be going south toward Rome. It is Florence, Venice, Pisa, Rome.
London is generally located to the northwest of Rome. If you were to travel from Rome to London, you would head in a northwestern direction. The exact angle can vary slightly depending on your specific starting and ending points within each city.
South East.
Away from rome
east and a little north
The Tiber runs south through central Italy and Rome to the sea west of Rome
Rome lies north and east from Carthage. When Hannibal attacked Rome, he actually took his troops over the Alps in northern Italy and came in from the north.
You would be going south toward Rome. It is Florence, Venice, Pisa, Rome.
You would be travelling eastwards.
Byzantium, which was redeveloped and renamed Constantinople by the emperor Constantine the Great as is now called Istanbul, lied/lies to the southeast of Rome.