It all depends where you start from and where you are travelling to. Most probable direction is west over the Pacific
north\east
east
East.
If you were travling from North America to Europe you would go North-East.
You would travel East to get from North America to Europe. The exact angle would depend on what your origin and destination are.
South-South-East
east.... i think
South.
south america
Travel north.
you would have to travel north
North