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If you would travel from Chicago to New Orleans you would be headed in a mostly south direction.
Ottawa in Canada is North of Panama. Thereflore the direction of travel is south. Panama City is in Panama, Central America.
Southwest
If you fly from Chicago to New Orleans what direction is it? SOUTH.
northeast
You would transit the Panama Canal going South.
You would travel east. However, if you were in Chicago Heights, you would travel north. If you were in East Chicago, you could travel north or east.
south
West
The direction from Chicago, IL to Detroit, MI is 80° compass heading, which is just north of heading east.
north west
If you were in downtown Chicago and headed to Oak Park, you would be heading west.