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The first Europeans in Japan were Portuguese.
They arrived coming from Macau (in China) were a Portuguese colony was already established in early 1530's. Some of the Portuguese arriving in Japan were sons of mixed marriages in India as well.
The date of the arrival in Kyushu island is somewhere between 1540 and 1545. The aim of the Portuguese sailors was to be the ones caring out the commerce between Japan and the rest of Asia. Missionaries, mainly the Jesuits, were sent to Japan and traveled in Portuguese ships as soon as the route was established.
During the period when Portugal and Spain had the same king (1580-1640) the route to Japan was still considered Portuguese and ruled by the "Estado da Índia", a branch of the Portuguese crown in India.
Around 1630 both the Portuguese and the Spanish were banned from Japan because the country closed itself from the Christian nations and most foreigner contact; and only allowed Chinese, Korean and Dutch to trade in some ports.
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