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Typically, ".exe" Application files only run on Windows PC's. Apple's OS X Applications are normally ".DMG" files.

So, unless you choose to install Windows on your Mac, using BootCamp, and a full, legal Windows Installation disk, those ".exe" files are no good to you.

TIP: Name the Windows App, and we may be able to offer you an OS X Alternative App.

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Q: What do you have to download to be able to open a exe file on a MacBook Pro?
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