It's just asking "You, how are you?"
The Spanish phrase Como esta tu trabajo means how is your work, in the English language. Spanish is spoken in almost all of Latin America.
how is your family
how is your family doing
Translation: Como esta tu querido hermano?
Como esta tu/su bebe (informal/formal)
En ingles, lo es "How is your sister?"
It is a reply to the question: como esta? (How are you?) Bien y tu is the reply (well, and you?)
It's actually, "¿Cómo estás (tú)?"; It means, "How are you?"
Come sta la tua madre?
"How is your stomach today, my friend?"
How is your mammy/mummy(assuming 'yu' should be 'tu')
Como se llama tu/su hermana (informal/formal)