It's just asking "You, how are you?"
The Spanish phrase Como esta tu trabajo means how is your work, in the English language. Spanish is spoken in almost all of Latin America.
how is your family
how is your family doing
Como esta tu/su bebe (informal/formal)
Translation: Como esta tu querido hermano?
En ingles, lo es "How is your sister?"
It's actually, "¿Cómo estás (tú)?"; It means, "How are you?"
"How is your stomach today, my friend?"
Come sta la tua madre?
How is your mammy/mummy(assuming 'yu' should be 'tu')
It is a reply to the question: como esta? (How are you?) Bien y tu is the reply (well, and you?)
Como se llama tu/su hermana (informal/formal)