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- Energetically favorable means that the input of energy is equal to or less than the output of energy.

- The output of energy is equal to or greater than the input of energy.

- The reaction is spontaneous.

When molecules/compounds/proteins/steroids/lipids/etc are made, bonds are broken and bonds are formed.

Breaking a bond always requires an input of energy (endothermic).

The formation of a bond, however, always releases energy (exothermic).

If the input of energy required to break a bond exceeds the release of energy to form a bond, then the formation of that bond/molecule/compound/protein/steroid/lipid/etc is not favorable.

In other words, if I have to pay a worker more than his work is worth, then his employment is not favorable.

For example, the formation of an ionic bond between lithium and chloride is energetically favorable because the input of energy required to remove an electron from lithium (ionization energy) is less than the energy released (electron affinity) when chloride gains an electron.

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Q: What does energetically favorable mean?
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