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Hellebore is a species of plant. It is said that Hippocrates used "white hellebore" (a false hellebore) as a purgative, a word for a strong laxative.

On that basis, "And for mathematical science he that doubts their certainty hath need of a dose of hellebore" would mean that the person has a need for a strong laxative. The reader is invited to interpret that in modern English, but there is a three-word expression that begins with "full of". ;-)

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Q: What does this quote meanAnd for mathematical science he that doubts their certainty hath need of a dose of hellebore?
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