It means, "Y'all's," or "thine;" that is, it means "your," (you plural familiar) and the noun is feminine. For a masculine noun the pronoun would then be "vuestro."
yours
And you? (formal "you" singular) Vd. refers to "usted" since the origin of the word "usted" is a contraction of "vuestra merced".
Without the first period, "vs.", it means the same as in English (versus). In capital leters, "V.S.", it may mean "vuestra santidad" (your holiness), among other things.
'Your little sister' in spanish is written and pronounced 'Tu hermana pequena'.
Su / tu / vuestra familia no tardará en venir aquí.Su / tu / vuestra familia pronto estará aquí (very literally)
Su / tu / vuestra casa.
¿A qué se debe su / tu / vuestra pregunta?
The derivation of the word "usted" is from the archaic form "vuestra merced", literally meaning "your mercy". This was a very common expression in 16th century Spanish (if you have ever read 'Don Quijote' you will have seen it often).
Su / tu / vuestra ropa está bonita.
Me fascina su / tu / vuestra nueva apariencia.
Su mamá (de usted) / tu mamá / vuestra mamá.
Me fascina su / tu / vuestra nueva apariencia.