In general terms, go to Cleveland, take I-77 South to I-23 East to I-95 South
The driving distance from Detroit, Michigan to Panama City, Florida is about 1,002 miles.
The driving distance from Detroit, Michigan to Naples, Florida is 1,338 miles / 2153 km
It is 988 miles from Detroit, Michigan, to Panama City Beach, Florida. This is about 15 hours and 5 minutes driving in the car.
MapQuest estimates the driving time as 18 hours and 28 minutes.
From Detroit, Michigan to Jacksonville, Florida it is 1,051 mi (about 16 hours 15 mins) driving. If you are talking about from Detroit to Jacksonville in a straight line it is 835 miles (1343 km).
The driving distance is about 125 miles.
About 105 miles.
215 miles.
165 miles.
About 53 miles.
The driving distance from Detroit, Michigan to Waterloo, Canada is 182 miles / 293 km
The driving distance from Boston, Massachusetts to Saint Augustine, Florida is 1,199 miles and about 20 hours behind the wheel.