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The subject of the verb 'do have' is 'risk factors', which is plural (it can be replaced by 'they'). Therefore the form of the verb must also be the plural form, which is 'do have' ('they do have', not 'they does have').

Do not be misled into thinking that the word 'effect', which is singular, is the subject of the verb 'do have' because it comes first. It is the object of that verb. Because the sentence is a question not a statement, the 'normal' word order for a statement (subject, verb, object) is reversed (object, auxiliary verb, subject, main verb). But it is still the subject that determines the form of the verb.

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Q: What effect do risk-factors have or what effect does risk-factors have Which is grammatically right?
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