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A "normal" cell does not divide into daughter cells without taking account of its environment. If energy sources are low in a medium, it will start a signaling system to suspend or even arrest the processes of the cell cycle. And if it makes contact with other cells---determined by proteins on the cell surface which may interact (bind specifically or nonspecifically) with the surface of the other cell (or its cell surface proteins), it may send a signal to do many things. Possibilities include arresting or even initiating a cell cycle (mitosis), altering its cytoskeleton (formation/deformation of microfiilaments and microtubules) to make a better fit or increase cell motility, or even altering its basic metabolism to acquire nutrients in a different manner or from an open (apical or basal) surface. In many cells, there is an inhibition ("contact inhibition") of the cell cycle when cell surfaces contact each other, which is why in culture growth is restricted to monolayers. Not in all cases...cancer cells may form piles or multilayers of cells and not be contact-inhibited.

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Q: What effect do the cells surrounding a normal cell have on the cell's growth and division?
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