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The medial septal nuclei are located in the anteroventral cerebrum. They have reciprocal connections to other parts of the limbic system; the hippocampus, amygdala, hypothalamus, cingulate gyrus, and thalamus. They are also connected to the midbrain. What we know most about the medial septal nuclei is that they play an important role in reward and reinforcement.

So, if the medial septal nuclei where stimulated, the brain would perceive a reward, a pleasurable sensation.

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