There are nearly 200:
There are a number of words with that letter combination. Examples include:bungburgdunghunglungrungsungpungtung
The first one that comes to mind is four; others are:anusaquablueblurboutchugchumclubcluecoupcrudcruxdaubdourdrugdrumfaunfauxfluxfoulglueglumglutgoutgrubhaulhourlaudloudloutmaulnounonusopusovumplugplumpluspoufpourpoutroutscumshunshutslugslumslursmugsmutsnubsnugsoulsoupsourspudtautthudthugthustourtrueyour
Ohio
have
Lake HURONSome words that have O as the second to last letter are:actorarborardorbloombroomcolordroopgloomgroomheronfloorfurormajormayormelonmoronmotorproofrumorsalonshootspoontumorvalorvaporwhoop
already
BiggerBetterHigher
geeseorderpriorteaseceaseleasedryerpeacepastaversemottosalsaparkanerveservetersekarmastartstintstiltaddedaidedmergeledgehedgesergewedgecallagammamannaseizeteaseerrorrodeopoliofencetensedensepencepandamambasambapapaw
Eleven letter words with second letter U, last letter R are:bullfighterbushwhackerquicksilverrumormongersupertankersurfboarder
Milk.
jump (as in long jump)
Some six letter words with the second letter U and the last letter E are:auntiebubblebucklebudgiebungleburglebustlebutanecuddlecurarecurdlecuttlefuddlefumblefutilefuturegurgleguzzlehuddlehumanehumblehurdlehurtlehustlejugglejujubejumblejunglejunkielupinelustremuddlemufflemumblemusclemutatemuzzlenuancenubilenuzzleoutagepuddlepumicepurplepursuepuzzlequichequincerubblerufflerumblerumplerustlesubduesubtlesucklesundaesupinesupplesuturetubuletumbleturtletusslevulvaeyuppie