it has been suggested that DNase1, part of the "junk" DNA in the nucleus, is responsible. I recall an experiment with mice where this gene was turned off and mice started presenting with signs of SLE.
There is no lupus gene. At this point, researchers have found 30 loci (locations) on the human genome that are implicated in the development of lupus.
Lupus is not caused by a pathogen. Lupus is not contagious.
The cause of lupus is not fully understood. The develpment of lupus contains a genetice component, gene expression, and environmental triggers.
Lupus anticoagulant is a blood clotting disorder that occurs in some lupus patients. Lupus anticoagulant causes blood clots. It is treated with blood thinners.
Lupus anticoagulant is one a several blood clotting disorders that can affect lupus patients. Lupus anticoagulant causes the patient to make blood clots. It is treated with blood thinners.
Yes. Autoimmune activity in lupus causes inflammation. Inflammation causes pain. 90-95% of lupus patients experience joint pain. Other pain may be present depending on which body systems and organs are involved.
Lupus anticoagulant does not, in itself cause tiredness but having lupus does. Lupus can cause anemia which in turn causes fatigue. Lupus can cause the body to make inflammatory cytokines which cause a feeling of flu like fatigue.
Most cases of lupus are mild to moderate, but some are fatal. Lupus causes profound fatigue and joint pain. In the worst cases, lupus can cause organ failure, heart attacks and strokes.
Identifying the faulty Gene. Identifying the faulty Gene that causes the disease.
Lupus can affect any and every part of the body. Most commonly, lupus causes profound fatigue and joint pain. 50% of lupus patients will have kidney involvement. Lupus frequently causes skin rashes and lesions. But lupus can attack any part of the body. Lupus does not spread in the sense of being contagious or like an infection-it is not. Lupus is an autoimmune disease in which the immune system turns against healthy parts of the self.
Idiopathic means they do not know what caused it. In that sense all lupus except drug induced or lupus caused by inhaling silica, is idiopathic because we do not know what causes it.
In adults, parvovirus can cause a prolonged and painful arthritis. There's no evidence, though, that it causes lupus.