Presumably died
In the play "Macbeth," Lady Macduff and her children are murdered by Macbeth's henchmen on Macbeth's orders. The murder is part of Macbeth's plan to secure his position as king by eliminating potential threats to his power.
Lady MacDuff and her children are killed in Act 4 of "Macbeth". Macbeth hires assassins to kill the MacDuff family because he fears MacDuff is plotting against him..
In the original version of the play (Shakespeare's) Macbeth and Lady Macbeth do not have any children. You might of watched/read/heard a different version...
How does lady macbeth cover for macbeth at the banquet?
In Act 1, Scene 5 of "Macbeth," Macbeth and Lady Macbeth discuss the prophecy given by the witches regarding Macbeth's future as king. Lady Macbeth urges Macbeth to seize the opportunity to become king by any means necessary, including murder. This conversation ultimately sets in motion the events that lead to Duncan's assassination and Macbeth's own downfall.
Lady Macbeth is the wife of the title character, Macbeth, a Scottish nobleman.
Prior to her marriage to Macbeth, Lady Macbeth was previously married to a guy called Gillecomlan, by whom she had a son. This is not stated in Shakespeare's play, but explains how Lady M has "given suck" while she and Macbeth have no children.
Lady Macbeth is often portrayed as a fourth witch.
Lady Macbeth
The reaction between Lady Macbeth and Macbeth is initially very different after they kill Duncan. Lady Macbeth is enthusiastic but Macbeth regrets his actions.
Lady Macbeth
Historically speaking, Lady Macbeth had a son by her first husband Gillecomlan called Lulach, who was adopted by his stepfather Macbeth. She and Macbeth had no children of their own. Although it was Lulach who became king after Macbeth, Shakespeare considered it dramatically unnecessary to include this fact in his play and so he does not appear. The idea that Lady M had been a mother makes sense of her line "I have given suck and know how tender 'tis to love the babe who milks me."