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The plague hit England around the time of Shakespeare
William Shakespeare never left England at any time.
William Shakespeare died in England in 1592. He was one of the most influential story tellers of all time.
Shakespeare never left England.
First, to be clear, Shakespeare had only one wife, not wives. Anne Shakespeare, like everyone else in England at the time, belonged to the Church of England.
In England alone, about five million people lived at the same time as Shakespeare.
England was at war with Spain which led to the attempt by Spain to invade England in 1588 when Will Shakespeare was 24.
The most significant war during Shakespeare's time was the Eighty Years' War (also known as the Dutch War of Independence) between the Dutch Republic and Spain. The war was fought for Dutch independence from Spanish rule and to establish the Protestant religion in the region.
William Shakespeare was 28 in 1592, at which time he was firmly installed in London. He didn't leave England at this time or probably at any time in his life.
Bear in mind that England was not part of the United Kingdom for about 100 years after Shakespeare's death. By the time the United Kingdom happened, Shakespeare was well-established as a cultural icon, and shortly thereafter David Garrick would boost his popularity even higher.
How where foreigners such as the Spanish, Portuguese, the French, the Jews, and the Africans treated in England during Shakespeare's time?
The Church of England