Insulin and epinephrine
After the NADH binds there the binding of pyruvate happens at the enzyme active site.
They are two different proteins, like the difference between a train and a robot. The difference between one protein and the other is the amino acid sequence that comprises that protein and the molecular bonding that determines its shape. Shape determines function in a protein. If it loses its shape it can't do its job. The shape of insulin and hemoglobin is different so insulin binds with glucose and hemoglobin binds with oxygen.
acts as a transcription factor and binds to DNA, activating a gene
tropomyosin moves out of the groove between the actin molecules.
It goes down
You can't produce insulin
Hyposecretion of insulin results in diabetes mellitus, which severely disturbs body metabolism.
If there is overproduction of insulin then your sugar is low all the time. You will be hypoglycemic all the time.
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They could become hypoglycemic, go into insulin shock, coma, and even death.
Then you can figure everything out, wella.