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One of the monokines, IL-1, is released from activated macrophages and damaged endothelium. IL-1 is the initial signal for activation of T-cells, neutrophils (in local inflammation). IL-1 stimulates bone marrow, acute-phase protein synthesis and is responsible for the induction of a fever (Staines et al, 1994).

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Q: What happens as a direct result when activated macrophages release the monokine called interleukin-1?
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