Check for large healthy cell, proper DNA replication, and nuclear cytoplasmic division.
There are typically four checkpoints in the cell cycle: the G1 checkpoint, G2 checkpoint, metaphase checkpoint, and the spindle checkpoint. These checkpoints help ensure that each stage of the cell cycle is completed accurately before progressing to the next stage.
Cell cycle
Once the checkpoint is passed in the cell cycle, the cell is committed to progressing through the next phase of division. The checkpoint ensures that the cell has accurately completed its previous phase before moving on to the next stage of the cell cycle. This helps maintain the integrity of the cell division process.
During the G2 phase of the cell cycle, the cell continues to grow and prepare for DNA replication. It is a checkpoint phase where the cell checks for any damage or errors before moving on to the next phase of the cycle. If conditions are favorable and the cell is healthy, it will proceed to the S phase for DNA replication.
If a cell does not pass the G1 checkpoint, it may enter a non-dividing phase called G0 or undergo apoptosis. This prevents the damaged cell from proceeding with the cell cycle and potentially forming tumors.
Checkpoints in the cell cycle regulate key points in the cell division process, including the G1/S checkpoint, the G2/M checkpoint, and the metaphase/anaphase checkpoint. These checkpoints ensure that critical cellular events, such as DNA replication and chromosome segregation, are accurately completed before proceeding to the next phase of the cell cycle. Failure to pass these checkpoints can result in cell cycle arrest or initiation of apoptosis.
The G1 checkpoint is the key decision point where the cell determines whether it will proceed with the cell division process. At this checkpoint, the cell assesses if conditions are favorable for division by checking for DNA damage, nutrient availability, and other factors before committing to enter the S phase of the cell cycle.
G2 checkpoint
Synthesis of DNA and many other cell organells take place during S-phase of cell cycle.
If the cell gets the go-ahead signal at this checkpoint, it usually completes the whole cell cycle and divides. If it does not receive the go-ahead signal it enters a non-dividing phase called G0 phase.
Nuclear division
The host cell is destroyed.