To destroy tissue in the GPi, a long needle-like probe is inserted deep into the brain, through a hole in the top of the skull. To make sure the probe reaches its target exactly, a rigid "stereotactic frame" is attached to the patient's head.
Pallidotomy is performed in the hospital by a neurosurgeon, in coordination with the patient's neurologist.
For unilateral pallidotomy, a single "burr hole" is made in the top of the skull; bilateral pallidotomy requires two holes.
Pallidotomy mimics this action by permanently destroying the GPi cells.
The key to successful outcome in pallidotomy is extremely precise placement of the electrode.
Since there are no pain receptors in the brain, there is no need for deeper anesthetic.
In a pallidotomy, the globus pallidus is destroyed by heat, delivered by long thin needles inserted under anesthesia
Unilateral (one-sided) pallidotomy may be used if symptoms are markedly worse on one side or the other, or if the risks from bilateral (two-sided) pallidotomy are judged to be too great.
During the procedure, the patient will be asked to make various movements to assist in determining the location of the electrode.
If bilateral pallidotomy is being performed, the localizing and lesioning will be repeated on the other side.
In addition, the patient must remain awake in order to report any sensory changes during the surgery.
Visual changes may indicate the probe is too close to this region.
Pallidotomy takes several hours to perform. In some medical centers, pallidotomy is performed as an outpatient procedure, and patients are sent home the same day. Most centers provide an overnight stay or longer for observation and recuperation