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The articles will break and fracture when a force is applied to them. These broken up particles will fill up void spaces, creating a larger surface area with new contact points. These new contact points will lead to a strengthened surface. Excipients which are known to undergo brittle fracture include lactose and Ca phosphate.

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What happens during plastic deformation for the excipients of drugs?

When a large force is being applied to the particles, deformation becomes irreversible. The applied force will cause the particles to change shape leading to void spaces being filled. Examples of excipients which are known to undergo plastic deformation when a force is applied to them include microcrystalline celluose and LHPC.


What is the importance of tests?

Impact test determines the amount of energy absorbed by a material during fracture. This absorbed energy is a measure of a given material's toughness and acts as a tool to study temperature-dependent brittle-ductile transition. It is to determine whether the material is brittle or ductile in nature.


What happens to a material during ductile deformation?

During ductile deformation, a material undergoes plastic deformation, meaning it permanently changes shape without breaking. This results in the material stretching and elongating before eventually yielding and forming necks or thin regions. The material exhibits a higher degree of deformation before fracture compared to brittle materials.


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Elastic deformation occurs when an opposing force is applied to the drug after particle rearrangement (i.e. the initial repacking of the particles). If the force is released before the yield point is reached, the particles of the drug will return to their original shape. However, if the force goes beyond the yield point, the powder will undergo plastic deformation or brittle fracture.


What is post weld heat treatment?

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What is a greenstick fracture?

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What is impact transition temperature for steel?

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What is a greenstick?

A greenstick fracture is afracture in a young, soft bone in which the bone bends and partially breaks. The bones become harder(calcified) and more brittle with age, it occurs almost exclusively during infancy and childhood when their bones are soft. The name is by analogy with green wood which similarly breaks on the outside when bent. There are three basic forms of greenstick fracture. In the first a transverse fracture occurs in the cortex, extends into the midportion of the bone and becomes oriented along the longitudinal axis of the bone without disrupting the opposite cortex. The second form is a torus or buckling fracture, caused by impaction. The third is a bow fracture in which the bone becomes curved along its longitudinal axis. A greenstick fracture is afracture in a young, soft bone in which the bone bends and partially breaks. The bones become harder(calcified) and more brittle with age, it occurs almost exclusively during infancy and childhood when their bones are soft. The name is by analogy with green wood which similarly breaks on the outside when bent. There are three basic forms of greenstick fracture. In the first a transverse fracture occurs in the cortex, extends into the midportion of the bone and becomes oriented along the longitudinal axis of the bone without disrupting the opposite cortex. The second form is a torus or buckling fracture, caused by impaction. The third is a bow fracture in which the bone becomes curved along its longitudinal axis.


What is the importance of impact test?

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Is igneous rock rigid and brittle?

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