You will cause severe engine wear.
Every Honda xr 80 ia a four-stroke, so no you don't need 2 cycle oil.
Engine will overheat. Possibly seizing the pistons and totally wrecking the engine.
Honda PE01E engine code - what model Honda motorcycle is this engine from?
The pistons hit the valves and your engine is basically ruined.
When you open the throttle the engine will hesitate.
Most Honda distribuitors has inside the ignition coil & pickup devices that produce the energy to fire up the combustion chambers allow the engine to "run" if you have a faulty distribuitor the engine won't start.
Almost always you will have bent valves and possible a busted piston. This is an interference engine.
If you continue to run the engine it will break down and seize up. The engine is likely to be beyond repair and need replacing.
The 2005 Honda Pilot has a V6 engine.
The 2010 Honda Pilot has a V6 engine.
The 2010 Honda Ridgeline has a V6 engine.
The 2012 Honda Pilot has a V6 engine.