What happens if Stardust Dragon attacks Wind-up Zenmaines in Yu-Gi-Oh?

Answer 1

Wind-Up Zenmaines has an effect to protect it from destruction, and if this happens, it then has a triggered destruction effect which triggers during the End Phase.

Stardust Dragon's negation effect can be chained to effects that activate and destroy on resolution. While there are ways around this by using effects that destroy the target later in the turn rather than on resolution, this is not the case.

Wind-Up Zenmaines will detach a card to protect itself, and then if the player wishes, can target and destroy one card in the end phase. Stardust Dragon's negation effect can be used against this. Now, if Zenmaines still has some material, it can protect itself once more from the destruction, but as its trigger is once per turn, could not activate that a second time.