He/She appoints a new vice president, and the U. S. Senate gets a new President Pro Tempore, which by tradition has been the most senior Senator.
The President pro tempore of the Senate is the next in line of succession after the Speaker of the House of Representatives.
President pro tempore of the Senate becomes President.
The Speaker of the House would never become President Pro Tempore, as that is an office within the Senate.
The President pro tempore of the Senate becomes the President. He/she is the leader of the Senate when the vice president can not attend. If him/her dies also then the Secretary of State becomes President.
President Pro Tempore of the Senate. The office also existed in the Confederate States of America.
The Speaker of the House of Representatives. If they can not serve, then the President pro tempore becomes the President.
President pro tempore President pro tempore President pro tempore
Assuming the President, Vice-President, Speaker of the House, and President Pro Tempore of the Senate are all dead the next in line for the Presidency would be the Secretary of State (Currently Hillary Rodham Clinton)
The 'President Pro Tempore' is the President of the Senate, when the Vice President of the United States is absent.
The President pro tempore of the Senate (the Senator elected as a leader by the other Senators).
The current president pro tempore is Daniel Inouye from Hawaii.
As the people's representative to make various legislation, this gives the members of the senate the honorary position.