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Assuming your refering to Activated sludge in the aeration basin, short term high D.O has little effect. However, long term over aeration can "burn out" microorganisms too fast, causing them to feed, replicate and die with increased speed and reduced efficiency. this can cause excess foaming (ashing) on the aeration basin. Also, certain fillamentous bacteria tend to outperform in excessively high D.O environments, causing fillamentous overgrowth in your clarifiers.

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