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It depens of your actual methadone dose and age (or other factors). Generally, you should avoid this combinaison and use another antibiotic.

However, if "cipro" is the only choice, make sure you check every parameters with your doctor and pharmacist.

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10y ago
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11y ago

Cipro affects the liver enzyme CYP3A4 which processes Methadone in the liver. Therefore the Methadone does not get processed out of the bloodstream properly, possibly leading to a Methadone overdose.

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10y ago

You cannot take methadone and penicillin together since you will end up into immediate withdrawal.

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Q: What happens if you mix methadone and cipro?
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