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As someone who has used Cocaine while taking Lexapro, I can tell you that it's not a happy outcome. The Cocaine high I experienced while also on Lexapro was the best I had ever had, simply an amazing feeling that didn't go away for 24 hours! Then, the next night I suddenly felt extreme anxiety and depression accompanied with thoughts of dread. I thought I should do more Cocaine to make these feelings go away, big mistake. The high I experienced this time was completely the opposite, now not only was I anxious and depressed, but I was wired and the stream of negative thoughts was flowing faster than before. Long story short, I then realized that Cocaine and Lexapro don't mix well, and as a result of that, I fell into a suicidal depression for the next week, until I was immediately taken off the Lexapro. The first time, the Cocaine and Lexapro made me feel better than I had ever felt before, but once I came down off this high, it was as if the Cocaine programmed my brain to react oppositely to the Lexapro, the days following the Lexapro made me feel more depressed, rather than it's usual anti-depressant properties. The Cocaine was like a switch that turned the Lexapro into a depressant rather than an anti-depressant. Don't do it!

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16y ago
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14y ago

Nothing. It's perfectly safe. Marijuana is neither a stimulant nor a depressant; it is actually a mild hallucinogen, and therefore it does not affect the heart or central nervous system the way most other drugs do. In fact, I do not know of a single drug or medication that is dangerous to take with marijuana.

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Q: What happens if you use cocaine while on Lexapro?
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