95, 64, 81, and 85 all cross major rivers.
A good site for finding a map of West Virginia's major roads and cities would be geology.com. It shows all of West Virginia's major interstates and cities, and has different types of map, depending on what you are looking for.
I don't know which are the major ones but there are 15 rivers in west Virginia
2,3,9,6,10,5
Mountains and rivers. They had plenty of lumber and fish.
highways and interstates
Interstates 40, 44 and 35
Interstate 70 and 25.
poo
The Blue Ridge Mountains and the Chesapeake Bay.
u.s. and state routes and interstates
There are generally 46 named rivers in the state of West Virginia exclusive of major tributaries and other smaller watercourses. However, this number is constantly debated as many of the major tributaries are large enough to be considered rivers in many other parts of the world. If one consults Wikipedia, they will find that there are approximately 82 named watercourses formally designated as rivers within the boundaries of the state.
Along the rivers. Those rivers were the major means of transport in the early days. Later, railroads would influence growth- for the same reason.