Florence, SC.
95 miles
255 miles taking this route:Take I-77 SOUTH (towards COLUMBIA), from Charlotte, to I-26 EAST to CHARLESTON (TO I-95) at END I-77 outside of Columbia, SOUTH CAROLINA.Take I-26 EAST across to I-95 SOUTH to SAVANNAH at EXIT 169A.Take I-95 SOUTH to SAVANNAH. To get to the city itself, take U.S. 17 SOUTH (EXIT 8 off I-95 in SOUTH CAROLINA).
665 miles taking this route:Take I-95 SOUTH from Eastchester down to I-85 via I-295 SOUTH to bypass RICHMOND. (EXIT 84A off I-95 in VIRGINIA to get onto I-295 SOUTH ; EXIT 1 off I-295 to get TO I-85, follow signs to I-85 SOUTH to SOUTH HILL.)Take I-85 SOUTH to Charlotte.
515 miles taking this route:Take I-85 SOUTH from Kannapolis to I-485 to ROCK HILL at EXIT 48.Take I-485 SOUTH around CHARLOTTE to I-77 to CHARLOTTE and COLUMBIA at EXIT 67; follow signs to I-77 SOUTH to COLUMBIA.Take I-77 SOUTH down to I-26 EAST to CHARLESTON (TO I-95) at END I-77 in COLUMBIA, SOUTH CAROLINA.Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.Take I-95 SOUTH thru South Carolina and Georgia to DAYTONA BEACH, FLORIDA.
The distance in miles from Oxford, MS to Charlotte, NC is 706 miles if you take the I-95.
500 miles taking this route:Take I-77 SOUTH from Charlotte to I-26 EAST to CHARLESTON (TO I-95) at END I-77 in Columbia, SOUTH CAROLINA.Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.Take I-95 SOUTH to I-10 WEST via I-295 SOUTH to bypass JACKSONVILLE (EXIT 362B off I-95 in FLORIDA to get onto I-295 SOUTH ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A near Lake City.Take I-75 SOUTH to Gainesville.
Take I-77 SOUTH from Charlotte to I-26 EAST to CHARLESTON (TO I-95) at END I-77 in COLUMBIA, SOUTH CAROLINA.Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.Take I-95 SOUTH to SR-200/A1A at EXIT 373 north of Jacksonville in FLORIDA.Turn left off the exit ramp, then follow SR-200 EAST to Fernandina Beach.
398 miles taking this route:Take I-95 SOUTH from Brunswick to I-10 WEST via I-295 SOUTH to bypass JACKSONVILLE (EXIT 362B off I-95 in FLORIDA to get onto I-295 SOUTH ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A near Lake City.Take I-75 SOUTH to Port Charlotte.
About 100 miles taking either I-95 SOUTH or Florida's TURNPIKE (toll) - SOUTH.
385 miles taking this route:Take I-95 NORTH, from Jacksonville, to I-26 WEST to COLUMBIA at EXIT 86B in SOUTH CAROLINA.Take I-26 WEST to I-77 NORTH to CHARLOTTE at EXIT 116, outside of Columbia.Take I-77 NORTH to CHARLOTTE.
578 miles taking this route:Take I-4 EAST from Lakeland to I-95 NORTH to JACKSONVILLE at END I-4 in DAYTONA BEACH.Take I-95 NORTH up to I-26 WEST to COLUMBIA at EXIT 86B in SOUTH CAROLINA.Take I-26 WEST to I-77 NORTH to CHARLOTTE at EXIT 116 near Columbia.Take I-77 NORTH to Charlotte.
174 miles taking this route:Take SR-105 WEST from Windsor to I-95 SOUTH to GARDNER in Augusta via U.S. 202/SR-11/17/100 WEST. When you are at I-95, follow signs to I-95 SOUTH.Take I-95 SOUTH to Boston.