It is not the oldest in the Americas, but is the largest. Its name is Mexico City.
tenochtitlan
Mexico City
Mexico City is the largest in the Americas and third largest in the world, behind Tokyo and Seoul.
tenochtitlan
yes
Los Angeles is America's 2nd largest city after New York City.
The largest city in the southern hemisphere is São Paulo, Brazil. With a population of over 12 million people, São Paulo is not only the largest city in the southern hemisphere but also the largest city in the Americas.
Mexico City is the largest city in the Americas. New York is the largest city in the US.
At its peak, Tenochtitlan was the largest city in the Pre-Columbian Americas. It covered an estimated 8 to 13.5 km2 (3.1 to 5.2 sq mi). Spanish conquistador Hernan Cortes arrived in Tenochtitlan on November 8, 1519, it had an estimated population between 200,000 and 300,000.
São Paulo is bigger than Mexico City in terms of population. São Paulo is the largest city in Brazil and the largest city proper in the Southern Hemisphere, while Mexico City is the largest city in Mexico.
The largest desert in the Americas is tthe Chihuahuan Desert.